相互作用
Arsenic trioxide + Ofloxacin
重症度: 重大
Arsenic trioxide and Ofloxacin: major interaction.
最終更新日
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概要
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and ofloxacin adds further risk. Together they may precipitate life-threatening ventricular arrhythmia.
この相互作用をわかりやすく説明すると
Arsenic trioxide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Ofloxacin belongs to Anti Bacterial.
なぜ起こるのか
Additive QT prolongation; arsenic trioxide alters cardiac ion currents and ofloxacin blocks hERG potassium channels.
対処法
Avoid the combination and choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Arsenic trioxideとOfloxacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ofloxacinのその他の相互作用
Arsenic trioxideのその他の相互作用
よくある質問
Can I take Arsenic trioxide with Ofloxacin?
MediHelp rates the interaction as major. Arsenic trioxide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and ofloxacin adds further risk. Together they may precipitate life-threatening ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
