相互作用
Asenapine + Carbidopa-levodopa
重症度: 重大
Asenapine and Carbidopa-levodopa: major interaction.
最終更新日
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概要
Asenapine blocks dopamine receptors and may antagonize the antiparkinsonian effect of levodopa, while both drugs can cause orthostatic hypotension. The combination may worsen parkinsonian symptoms and increase dizziness or falls.
この相互作用をわかりやすく説明すると
Asenapine and Carbidopa-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Carbidopa-levodopa belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism at dopamine D2 receptors, plus additive orthostatic hypotension through alpha-1 blockade and levodopa effects.
対処法
Avoid in Parkinson disease if possible, preferring low-D2-affinity agents such as quetiapine or clozapine when an antipsychotic is needed; monitor motor function and orthostatic blood pressure.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AsenapineとCarbidopa-levodopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-levodopaのその他の相互作用
Asenapineのその他の相互作用
よくある質問
Can I take Asenapine with Carbidopa-levodopa?
MediHelp rates the interaction as major. Asenapine and Carbidopa-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asenapine blocks dopamine receptors and may antagonize the antiparkinsonian effect of levodopa, while both drugs can cause orthostatic hypotension. The combination may worsen parkinsonian symptoms and increase dizziness or falls.
How serious is the interaction between Asenapine and Carbidopa-levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson disease if possible, preferring low-D2-affinity agents such as quetiapine or clozapine when an antipsychotic is needed; monitor motor function and orthostatic blood pressure.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
