相互作用
Carbidopa-levodopa + Chlorpromazine
重症度: 重大
Carbidopa-levodopa and Chlorpromazine: major interaction.
最終更新日
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概要
Chlorpromazine is a potent dopamine blocker that can negate levodopa benefit and cause or worsen parkinsonism. Orthostatic hypotension may also be additive.
この相互作用をわかりやすく説明すると
Carbidopa-levodopa and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbidopa-levodopa belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism: D2 receptor blockade by chlorpromazine opposes levodopa.
対処法
Avoid in Parkinson's disease and use an alternative such as low-dose quetiapine or clozapine. If unavoidable, monitor motor function and blood pressure.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Carbidopa-levodopaとChlorpromazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-levodopaのその他の相互作用
Chlorpromazineのその他の相互作用
よくある質問
Can I take Carbidopa-levodopa with Chlorpromazine?
MediHelp rates the interaction as major. Carbidopa-levodopa and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine is a potent dopamine blocker that can negate levodopa benefit and cause or worsen parkinsonism. Orthostatic hypotension may also be additive.
How serious is the interaction between Carbidopa-levodopa and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson's disease and use an alternative such as low-dose quetiapine or clozapine. If unavoidable, monitor motor function and blood pressure.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
