相互作用
Carbidopa-levodopa + Isocarboxazid
重症度: 併用禁忌
Carbidopa-levodopa and Isocarboxazid: contraindicated interaction.
最終更新日
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概要
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Severe hypertension, flushing, headache and hyperpyrexia may follow.
この相互作用をわかりやすく説明すると
Carbidopa-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-levodopa belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
なぜ起こるのか
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines
対処法
Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Carbidopa-levodopaとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-levodopaのその他の相互作用
Isocarboxazidのその他の相互作用
よくある質問
Can I take Carbidopa-levodopa with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Carbidopa-levodopa and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (isocarboxazid) prevents their breakdown so the amines accumulate. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-levodopa and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Phenelzine, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
