相互作用
Asenapine + Pasireotide
重症度: 重大
Asenapine and Pasireotide: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, and pasireotide also causes bradycardia. Combined use raises the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Asenapine and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Pasireotide belongs to Endocrine.
なぜ起こるのか
Additive QTc prolongation, with bradycardia from pasireotide.
対処法
Obtain a baseline ECG and monitor it periodically. Correct hypokalemia and hypomagnesemia before and during therapy.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AsenapineとPasireotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Asenapineのその他の相互作用
Pasireotideのその他の相互作用
よくある質問
Can I take Asenapine with Pasireotide?
MediHelp rates the interaction as major. Asenapine and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and pasireotide also causes bradycardia. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Asenapine and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically. Correct hypokalemia and hypomagnesemia before and during therapy.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
