医薬品リファレンス
Pasireotide
Pasireotide is a medicine in the class endocrine. It is used for cushing syndrome.
- 薬効分類: Endocrine
- 効能・効果: cushing syndrome
最終更新日 出典: US FDA label
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要点
- 薬効分類
- Endocrine
- ATCコード
- H01CB05
- 一般的な剤形
- 注射剤
- 一般的な規格
- 20 mg
- 既知の相互作用
- 125 (併用禁忌: 2 · 重大: 44 · 中等度: 78 · 軽度: 1)
- 商品名
- 3
- 国・市場
- 3
何に使われるか
作用のしくみ
Injectable cyclohexapeptide somatostatin analogue that binds and activates somatostatin receptors (notably SSTR5, over-expressed in corticotroph tumors), inhibiting ACTH secretion and thereby decreasing cortisol secretion.
成人の通常用量（添付文書の要約）
Cushing's disease: initial 0.6 mg or 0.9 mg subcutaneously twice a day; range 0.3 mg to 0.9 mg twice a day; titrate to response and tolerability
妊娠と授乳
- 妊娠
- Unknown Limited human data. In rabbits it caused developmental delay at doses below human exposure without maternal toxicity; in rats, malrotated limbs at very high doses. EU label: not recommended in pregnancy; women may become fertile again as cortisol or GH falls, so use contraception.
- 授乳
- Unknown No human milk data; passes into rat milk. EU label: stop breastfeeding during treatment; US label: weigh benefits. LactMed: a large peptide, likely poorly excreted and digested by the infant, but an alternate drug is preferred.
報告されている副作用
- Diarrhea
- Nausea
- Hyperglycemia
- Cholelithiasis
- Headache
- Abdominal pain
禁忌
- None.
注意が必要な方
- Hypocortisolism may occur; monitor, and consider dose reduction or interruption and temporary glucocorticoid replacement.
- Hyperglycemia and diabetes: monitor glycemia weekly for first two to three months and after dose increases; optimize antidiabetic therapy before starting.
- Bradycardia and QT prolongation: use caution in at-risk patients; baseline ECG recommended; correct hypokalemia and hypomagnesemia.
妊娠中または授乳中であること、腎臓や肝臓の病気、アレルギー、ほかに使用しているすべての薬やサプリメントについて、薬剤師または医師にお伝えください。
主な相互作用 (125)
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
- Asenapine + Pasireotide Major
- Azithromycin + Pasireotide Major
- Citalopram + Pasireotide Major
- Clarithromycin + Pasireotide Major
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Pasireotideの完全なモノグラフ（用量、妊娠・授乳、副作用、警告、すべての相互作用）を表示できます。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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同じ分類のほかの薬剤
よくある質問
What is Pasireotide used for?
Pasireotide is a medicine in the class endocrine. It is used for Cushing syndrome.
What side effects have been reported with Pasireotide?
Diarrhea, Nausea, Hyperglycemia, Cholelithiasis, Headache, Abdominal pain.
Can Pasireotide be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. In rabbits it caused developmental delay at doses below human exposure without maternal toxicity; in rats, malrotated limbs at very high doses. EU label: not recommended in pregnancy; women may become fertile again as cortisol or GH falls, so use contraception. Breastfeeding: Unknown. No human milk data; passes into rat milk. EU label: stop breastfeeding during treatment; US label: weigh benefits. LactMed: a large peptide, likely poorly excreted and digested by the infant, but an alternate drug is preferred.
What does Pasireotide interact with?
MediHelp lists 125 known interactions for Pasireotide. Contraindicated: 2 · Major: 44 · Moderate: 78 · Minor: 1. The most serious include Dronedarone, Pimozide, Amiodarone.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
