相互作用
Amitriptyline + Pasireotide
重症度: 重大
Amitriptyline and Pasireotide: major interaction.
最終更新日
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概要
Both drugs can prolong the QT interval, and pasireotide may also cause bradycardia, which increases the risk of torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia or underlying heart disease.
この相互作用をわかりやすく説明すると
Amitriptyline and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Pasireotide belongs to Endocrine.
なぜ起こるのか
Additive prolongation of cardiac repolarization, with pasireotide-related bradycardia increasing the arrhythmic risk.
対処法
Obtain a baseline ECG and monitor it during treatment, and correct potassium and magnesium abnormalities before and during therapy. Consider an alternative to amitriptyline if QTc becomes prolonged.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmitriptylineとPasireotideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Amitriptylineのその他の相互作用
Pasireotideのその他の相互作用
よくある質問
Can I take Amitriptyline with Pasireotide?
MediHelp rates the interaction as major. Amitriptyline and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and pasireotide may also cause bradycardia, which increases the risk of torsades de pointes. The risk is higher with hypokalemia, hypomagnesemia or underlying heart disease.
How serious is the interaction between Amitriptyline and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment, and correct potassium and magnesium abnormalities before and during therapy. Consider an alternative to amitriptyline if QTc becomes prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
