相互作用
Asenapine transdermal + Carbidopa-entacapone-levodopa
重症度: 重大
Asenapine transdermal and Carbidopa-entacapone-levodopa: major interaction.
最終更新日
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概要
Asenapine is a dopamine antagonist and can oppose the effect of levodopa, worsening parkinsonian symptoms. Additive sedation and orthostatic hypotension can also occur.
この相互作用をわかりやすく説明すると
Asenapine transdermal and Carbidopa-entacapone-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Pharmacodynamic antagonism at dopamine D2 receptors plus additive sedative and hypotensive effects.
対処法
Avoid in Parkinson's disease where possible; if an antipsychotic is needed, use quetiapine or clozapine and monitor motor function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Asenapine transdermalとCarbidopa-entacapone-levodopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-entacapone-levodopaのその他の相互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 併用禁忌
- Carbidopa-entacapone-levodopa + Phenelzine 併用禁忌
- Carbidopa-entacapone-levodopa + Selegiline transdermal 併用禁忌
- Carbidopa-entacapone-levodopa + Tranylcypromine 併用禁忌
- Amisulpride + Carbidopa-entacapone-levodopa 重大
- Carbidopa-entacapone-levodopa + Chlorpromazine 重大
よくある質問
Can I take Asenapine transdermal with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as major. Asenapine transdermal and Carbidopa-entacapone-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Asenapine is a dopamine antagonist and can oppose the effect of levodopa, worsening parkinsonian symptoms. Additive sedation and orthostatic hypotension can also occur.
How serious is the interaction between Asenapine transdermal and Carbidopa-entacapone-levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in Parkinson's disease where possible; if an antipsychotic is needed, use quetiapine or clozapine and monitor motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
