相互作用
Carbidopa-entacapone-levodopa + Chlorpromazine
重症度: 重大
Carbidopa-entacapone-levodopa and Chlorpromazine: major interaction.
最終更新日
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概要
Chlorpromazine blocks dopamine receptors and can markedly worsen parkinsonism, negating the benefit of levodopa. Levodopa may also reduce the antipsychotic effect.
この相互作用をわかりやすく説明すると
Carbidopa-entacapone-levodopa and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Chlorpromazine belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism through D2 receptor blockade.
対処法
Avoid chlorpromazine in patients taking levodopa. Use quetiapine or clozapine if an antipsychotic is needed, and monitor motor function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Carbidopa-entacapone-levodopaとChlorpromazineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-entacapone-levodopaのその他の相互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 併用禁忌
- Carbidopa-entacapone-levodopa + Phenelzine 併用禁忌
- Carbidopa-entacapone-levodopa + Selegiline transdermal 併用禁忌
- Carbidopa-entacapone-levodopa + Tranylcypromine 併用禁忌
- Amisulpride + Carbidopa-entacapone-levodopa 重大
- Asenapine transdermal + Carbidopa-entacapone-levodopa 重大
Chlorpromazineのその他の相互作用
よくある質問
Can I take Carbidopa-entacapone-levodopa with Chlorpromazine?
MediHelp rates the interaction as major. Carbidopa-entacapone-levodopa and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpromazine blocks dopamine receptors and can markedly worsen parkinsonism, negating the benefit of levodopa. Levodopa may also reduce the antipsychotic effect.
How serious is the interaction between Carbidopa-entacapone-levodopa and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chlorpromazine in patients taking levodopa. Use quetiapine or clozapine if an antipsychotic is needed, and monitor motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
