相互作用
Amisulpride + Carbidopa-entacapone-levodopa
重症度: 重大
Amisulpride and Carbidopa-entacapone-levodopa: major interaction.
最終更新日
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概要
Amisulpride blocks dopamine D2/D3 receptors and opposes the antiparkinsonian effect of levodopa, which can worsen motor symptoms. Levodopa may in turn reduce the antipsychotic effect.
この相互作用をわかりやすく説明すると
Amisulpride and Carbidopa-entacapone-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Carbidopa-entacapone-levodopa belongs to Central Nervous System.
なぜ起こるのか
Pharmacodynamic antagonism between a dopamine receptor antagonist and dopamine replacement therapy.
対処法
Avoid the combination in Parkinson's disease where possible. If an antipsychotic is required, choose quetiapine or clozapine at the lowest effective dose and monitor motor function.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmisulprideとCarbidopa-entacapone-levodopaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbidopa-entacapone-levodopaのその他の相互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 併用禁忌
- Carbidopa-entacapone-levodopa + Phenelzine 併用禁忌
- Carbidopa-entacapone-levodopa + Selegiline transdermal 併用禁忌
- Carbidopa-entacapone-levodopa + Tranylcypromine 併用禁忌
- Asenapine transdermal + Carbidopa-entacapone-levodopa 重大
- Carbidopa-entacapone-levodopa + Chlorpromazine 重大
Amisulprideのその他の相互作用
よくある質問
Can I take Amisulpride with Carbidopa-entacapone-levodopa?
MediHelp rates the interaction as major. Amisulpride and Carbidopa-entacapone-levodopa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride blocks dopamine D2/D3 receptors and opposes the antiparkinsonian effect of levodopa, which can worsen motor symptoms. Levodopa may in turn reduce the antipsychotic effect.
How serious is the interaction between Amisulpride and Carbidopa-entacapone-levodopa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in Parkinson's disease where possible. If an antipsychotic is required, choose quetiapine or clozapine at the lowest effective dose and monitor motor function.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
