相互作用
Atezolizumab + Piperacillin-tazobactam
重症度: 軽度
Atezolizumab and Piperacillin-tazobactam: minor interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Observational data link antibiotic exposure around the start of immune checkpoint inhibitor therapy with poorer outcomes, possibly through gut microbiome disruption. The evidence is associative and confounded by patient illness severity. The effect on any individual patient is uncertain.
この相互作用をわかりやすく説明すると
Atezolizumab and Piperacillin-tazobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atezolizumab belongs to Oncology; Piperacillin-tazobactam belongs to Anti Bacterial.
なぜ起こるのか
Proposed disruption of gut microbiota that may modulate antitumor immune response; not firmly established.
対処法
Use the antibiotic only for a clear indication and de-escalate or stop as soon as culture results and clinical status allow. Do not withhold needed antibiotics.
薬剤師に尋ねること
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtezolizumabとPiperacillin-tazobactamの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Piperacillin-tazobactamのその他の相互作用
Atezolizumabのその他の相互作用
よくある質問
Can I take Atezolizumab with Piperacillin-tazobactam?
MediHelp rates the interaction as minor. Atezolizumab and Piperacillin-tazobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Observational data link antibiotic exposure around the start of immune checkpoint inhibitor therapy with poorer outcomes, possibly through gut microbiome disruption. The evidence is associative and confounded by patient illness severity. The effect on any individual patient is uncertain.
How serious is the interaction between Atezolizumab and Piperacillin-tazobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the antibiotic only for a clear indication and de-escalate or stop as soon as culture results and clinical status allow. Do not withhold needed antibiotics.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
