相互作用
Atogepant + Chloramphenicol
重症度: 中等度
Atogepant and Chloramphenicol: moderate interaction.
最終更新日
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概要
Chloramphenicol may inhibit CYP3A4 and increase atogepant exposure, raising the risk of adverse effects such as constipation, nausea and fatigue. Labeling recommends a lower atogepant dose with strong CYP3A4 inhibitors.
この相互作用をわかりやすく説明すると
Atogepant and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Chloramphenicol belongs to Anti Bacterial.
なぜ起こるのか
Inhibition of CYP3A4-mediated metabolism of atogepant.
対処法
Limit atogepant to the reduced dose recommended for strong CYP3A4 inhibitors during chloramphenicol therapy. Monitor for adverse effects.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtogepantとChloramphenicolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chloramphenicolのその他の相互作用
Atogepantのその他の相互作用
よくある質問
Can I take Atogepant with Chloramphenicol?
MediHelp rates the interaction as moderate. Atogepant and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol may inhibit CYP3A4 and increase atogepant exposure, raising the risk of adverse effects such as constipation, nausea and fatigue. Labeling recommends a lower atogepant dose with strong CYP3A4 inhibitors.
How serious is the interaction between Atogepant and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to the reduced dose recommended for strong CYP3A4 inhibitors during chloramphenicol therapy. Monitor for adverse effects.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
