相互作用
Avapritinib + Chloramphenicol
重症度: 重大
Avapritinib and Chloramphenicol: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Avapritinib is a CYP3A4 substrate and its exposure increases with CYP3A4 inhibitors, raising the risk of cognitive effects, intracranial bleeding and other toxicity. Chloramphenicol is a CYP3A4 inhibitor, though likely weaker than strong inhibitors.
この相互作用をわかりやすく説明すると
Avapritinib and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avapritinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
なぜ起こるのか
Inhibition of CYP3A4-mediated metabolism of avapritinib.
対処法
Avoid the combination and choose another antibiotic. If necessary, monitor for cognitive changes, bleeding and other adverse effects, and consider avapritinib dose reduction.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvapritinibとChloramphenicolの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Chloramphenicolのその他の相互作用
Avapritinibのその他の相互作用
よくある質問
Can I take Avapritinib with Chloramphenicol?
MediHelp rates the interaction as major. Avapritinib and Chloramphenicol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Avapritinib is a CYP3A4 substrate and its exposure increases with CYP3A4 inhibitors, raising the risk of cognitive effects, intracranial bleeding and other toxicity. Chloramphenicol is a CYP3A4 inhibitor, though likely weaker than strong inhibitors.
How serious is the interaction between Avapritinib and Chloramphenicol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antibiotic. If necessary, monitor for cognitive changes, bleeding and other adverse effects, and consider avapritinib dose reduction.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Bcg vaccine live, Benzhydrocodone / acetaminophen. The full list is on the Chloramphenicol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
