相互作用
Chloramphenicol + Colchicine
重症度: 重大
Chloramphenicol and Colchicine: major interaction.
最終更新日
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概要
Chloramphenicol can inhibit CYP3A4 and may raise colchicine concentrations. Higher exposure raises the risk of colchicine toxicity including GI effects, myopathy and bone marrow suppression.
この相互作用をわかりやすく説明すると
Chloramphenicol and Colchicine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Colchicine belongs to Genitourinary.
なぜ起こるのか
Inhibition of CYP3A4 reduces colchicine metabolism.
対処法
Reduce the colchicine dose or avoid the combination, and monitor for toxicity and blood counts. Avoid it altogether in renal or hepatic impairment.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ChloramphenicolとColchicineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Colchicineのその他の相互作用
Chloramphenicolのその他の相互作用
よくある質問
Can I take Chloramphenicol with Colchicine?
MediHelp rates the interaction as major. Chloramphenicol and Colchicine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chloramphenicol can inhibit CYP3A4 and may raise colchicine concentrations. Higher exposure raises the risk of colchicine toxicity including GI effects, myopathy and bone marrow suppression.
How serious is the interaction between Chloramphenicol and Colchicine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose or avoid the combination, and monitor for toxicity and blood counts. Avoid it altogether in renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
