相互作用
Atogepant + Crizotinib
重症度: 中等度
Atogepant and Crizotinib: moderate interaction.
最終更新日
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概要
Crizotinib is a moderate CYP3A4 inhibitor and can raise atogepant exposure. This may increase atogepant adverse effects such as nausea, constipation and fatigue.
この相互作用をわかりやすく説明すると
Atogepant and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Crizotinib belongs to Oncology.
なぜ起こるのか
Crizotinib inhibits CYP3A4-mediated metabolism of atogepant, increasing its exposure.
対処法
Limit atogepant to a reduced dose of 10 mg daily for the prevention of episodic migraine when used with a CYP3A4 inhibitor, and monitor tolerability.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtogepantとCrizotinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Crizotinibのその他の相互作用
Atogepantのその他の相互作用
よくある質問
Can I take Atogepant with Crizotinib?
MediHelp rates the interaction as moderate. Atogepant and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and can raise atogepant exposure. This may increase atogepant adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to a reduced dose of 10 mg daily for the prevention of episodic migraine when used with a CYP3A4 inhibitor, and monitor tolerability.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
