相互作用
Atorvastatin + Letermovir
重症度: 重大
Atorvastatin and Letermovir: major interaction.
最終更新日
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概要
Letermovir increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin may also affect letermovir through OATP1B1/3 competition, though this is less important.
この相互作用をわかりやすく説明すると
Atorvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atorvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.
なぜ起こるのか
Letermovir inhibits CYP3A4 and OATP1B1/3, reducing atorvastatin metabolism and hepatic uptake.
対処法
Limit atorvastatin to no more than 20 mg daily and monitor for myopathy. Avoid atorvastatin if letermovir is given with cyclosporine.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtorvastatinとLetermovirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Atorvastatinのその他の相互作用
Letermovirのその他の相互作用
よくある質問
Can I take Atorvastatin with Letermovir?
MediHelp rates the interaction as major. Atorvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin may also affect letermovir through OATP1B1/3 competition, though this is less important.
How serious is the interaction between Atorvastatin and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atorvastatin to no more than 20 mg daily and monitor for myopathy. Avoid atorvastatin if letermovir is given with cyclosporine.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
