相互作用
Apalutamide + Letermovir
重症度: 重大
Apalutamide and Letermovir: major interaction.
最終更新日
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概要
Apalutamide may lower letermovir concentrations by inducing its elimination pathways. Reduced letermovir exposure may weaken CMV prophylaxis.
この相互作用をわかりやすく説明すると
Apalutamide and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Letermovir belongs to Anti Virals.
なぜ起こるのか
Induction of UGT1A1/3 and P-glycoprotein by apalutamide is expected to enhance letermovir clearance.
対処法
Avoid the combination as recommended in letermovir labeling for inducers of these pathways. If it must be used, monitor for CMV breakthrough.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ApalutamideとLetermovirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Apalutamideのその他の相互作用
Letermovirのその他の相互作用
よくある質問
Can I take Apalutamide with Letermovir?
MediHelp rates the interaction as major. Apalutamide and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may lower letermovir concentrations by inducing its elimination pathways. Reduced letermovir exposure may weaken CMV prophylaxis.
How serious is the interaction between Apalutamide and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination as recommended in letermovir labeling for inducers of these pathways. If it must be used, monitor for CMV breakthrough.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
