相互作用
Atorvastatin + Vadadustat
重症度: 中等度
Atorvastatin and Vadadustat: moderate interaction.
最終更新日
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概要
Vadadustat inhibits BCRP and can increase exposure to BCRP substrates such as atorvastatin. This may increase the risk of statin-related muscle adverse effects.
この相互作用をわかりやすく説明すると
Atorvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Vadadustat belongs to Endocrine.
なぜ起こるのか
Vadadustat inhibits breast cancer resistance protein (BCRP), reducing atorvastatin efflux and increasing its systemic exposure.
対処法
Monitor for myalgia and consider reducing the atorvastatin dose if symptoms develop. Check creatine kinase when muscle symptoms occur.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtorvastatinとVadadustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Atorvastatinのその他の相互作用
Vadadustatのその他の相互作用
よくある質問
Can I take Atorvastatin with Vadadustat?
MediHelp rates the interaction as moderate. Atorvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and can increase exposure to BCRP substrates such as atorvastatin. This may increase the risk of statin-related muscle adverse effects.
How serious is the interaction between Atorvastatin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider reducing the atorvastatin dose if symptoms develop. Check creatine kinase when muscle symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
