相互作用
Balsalazide + Vadadustat
重症度: 中等度
Balsalazide and Vadadustat: moderate interaction.
最終更新日
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概要
Vadadustat is an OAT1/OAT3 substrate, and balsalazide or its salicylate metabolites may inhibit these transporters. Vadadustat exposure may rise, causing an excessive hemoglobin increase and more adverse reactions.
この相互作用をわかりやすく説明すると
Balsalazide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Balsalazide belongs to Gastrointestinal Tract; Vadadustat belongs to Endocrine.
なぜ起こるのか
Inhibition of renal OAT1/OAT3 transport reduces vadadustat clearance.
対処法
Monitor hemoglobin closely and adjust vadadustat dose according to labeling if the rise is too rapid.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BalsalazideとVadadustatの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Balsalazideのその他の相互作用
Vadadustatのその他の相互作用
よくある質問
Can I take Balsalazide with Vadadustat?
MediHelp rates the interaction as moderate. Balsalazide and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat is an OAT1/OAT3 substrate, and balsalazide or its salicylate metabolites may inhibit these transporters. Vadadustat exposure may rise, causing an excessive hemoglobin increase and more adverse reactions.
How serious is the interaction between Balsalazide and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and adjust vadadustat dose according to labeling if the rise is too rapid.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
