相互作用
Atracurium + Magnesium
重症度: 中等度
Atracurium and Magnesium: moderate interaction.
最終更新日
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概要
Parenteral magnesium sulfate potentiates and prolongs neuromuscular blockade from atracurium. This may lead to delayed recovery and prolonged respiratory muscle weakness.
この相互作用をわかりやすく説明すると
Atracurium and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atracurium belongs to Musculoskeletal; Magnesium belongs to Gastrointestinal Tract.
なぜ起こるのか
Magnesium reduces presynaptic acetylcholine release and lowers postsynaptic sensitivity, adding to nondepolarizing blockade.
対処法
Reduce neuromuscular blocker dose and monitor with train-of-four. Be prepared for prolonged ventilatory support.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AtracuriumとMagnesiumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Magnesiumのその他の相互作用
Atracuriumのその他の相互作用
よくある質問
Can I take Atracurium with Magnesium?
MediHelp rates the interaction as moderate. Atracurium and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates and prolongs neuromuscular blockade from atracurium. This may lead to delayed recovery and prolonged respiratory muscle weakness.
How serious is the interaction between Atracurium and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce neuromuscular blocker dose and monitor with train-of-four. Be prepared for prolonged ventilatory support.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
