相互作用
Avanafil + Conivaptan
重症度: 併用禁忌
Avanafil and Conivaptan: contraindicated interaction.
最終更新日
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概要
Conivaptan is a strong CYP3A4 inhibitor and can markedly raise avanafil levels. Excess PDE5 inhibition may cause severe hypotension, syncope, visual changes and priapism.
この相互作用をわかりやすく説明すると
Avanafil and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
CYP3A4 inhibition by conivaptan decreases avanafil clearance.
対処法
Avoid avanafil during conivaptan therapy. Use an alternative erectile dysfunction treatment if needed.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AvanafilとConivaptanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Avanafilのその他の相互作用
よくある質問
Can I take Avanafil with Conivaptan?
MediHelp rates the interaction as contraindicated. Avanafil and Conivaptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a strong CYP3A4 inhibitor and can markedly raise avanafil levels. Excess PDE5 inhibition may cause severe hypotension, syncope, visual changes and priapism.
How serious is the interaction between Avanafil and Conivaptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid avanafil during conivaptan therapy. Use an alternative erectile dysfunction treatment if needed.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
