相互作用
Bacillus calmette-guerin substrain tice + Isoniazid
重症度: 重大
Bacillus calmette-guerin substrain tice and Isoniazid: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
BCG is a live attenuated Mycobacterium bovis, and isoniazid is active against mycobacteria, so it can reduce the viability and effect of intravesical BCG. This can lower the efficacy of bladder cancer immunotherapy.
この相互作用をわかりやすく説明すると
Bacillus calmette-guerin substrain tice and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacillus calmette-guerin substrain tice belongs to Oncology; Isoniazid belongs to Anti Bacterial.
なぜ起こるのか
Antimycobacterial activity of isoniazid against the live BCG organisms reduces their viability and therefore immunotherapeutic activity.
対処法
Avoid giving antituberculosis drugs during intravesical BCG therapy unless needed to treat BCG infection. Use alternative non-antimycobacterial agents for local irritative symptoms.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Bacillus calmette-guerin substrain ticeとIsoniazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isoniazidのその他の相互作用
よくある質問
Can I take Bacillus calmette-guerin substrain tice with Isoniazid?
MediHelp rates the interaction as major. Bacillus calmette-guerin substrain tice and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. BCG is a live attenuated Mycobacterium bovis, and isoniazid is active against mycobacteria, so it can reduce the viability and effect of intravesical BCG. This can lower the efficacy of bladder cancer immunotherapy.
How serious is the interaction between Bacillus calmette-guerin substrain tice and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving antituberculosis drugs during intravesical BCG therapy unless needed to treat BCG infection. Use alternative non-antimycobacterial agents for local irritative symptoms.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Benzhydrocodone / acetaminophen, Carbamazepine, Didanosine. The full list is on the Isoniazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
