相互作用
Ergotamine + Isoniazid
重症度: 重大
Ergotamine and Isoniazid: major interaction.
最終更新日
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概要
Ergotamine levels rise when CYP3A4 is inhibited, and this can lead to ergotism with severe peripheral vasospasm and ischemia. Isoniazid is a weaker CYP3A4 inhibitor than macrolides or azoles, but the potential toxicity is serious.
この相互作用をわかりやすく説明すると
Ergotamine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
なぜ起こるのか
Isoniazid inhibits CYP3A4, reducing ergotamine clearance.
対処法
Avoid the combination where possible and use a non-ergot migraine treatment. If used, counsel the patient to report numbness, coldness or pain in the limbs promptly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ErgotamineとIsoniazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isoniazidのその他の相互作用
Ergotamineのその他の相互作用
よくある質問
Can I take Ergotamine with Isoniazid?
MediHelp rates the interaction as major. Ergotamine and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ergotamine levels rise when CYP3A4 is inhibited, and this can lead to ergotism with severe peripheral vasospasm and ischemia. Isoniazid is a weaker CYP3A4 inhibitor than macrolides or azoles, but the potential toxicity is serious.
How serious is the interaction between Ergotamine and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use a non-ergot migraine treatment. If used, counsel the patient to report numbness, coldness or pain in the limbs promptly.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
