相互作用
Benzhydrocodone / acetaminophen + Isoniazid
重症度: 重大
Benzhydrocodone / acetaminophen and Isoniazid: major interaction.
最終更新日
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概要
Isoniazid inhibits CYP3A4, which clears hydrocodone, so opioid exposure can increase and risk respiratory depression and sedation. Isoniazid and acetaminophen both carry hepatotoxic potential, with isoniazid possibly increasing toxic acetaminophen metabolite formation.
この相互作用をわかりやすく説明すると
Benzhydrocodone / acetaminophen and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
CYP3A4 inhibition raises hydrocodone levels, and isoniazid-related CYP2E1 effects plus additive hepatotoxicity apply to acetaminophen.
対処法
Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Monitor liver function and limit acetaminophen total daily dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Benzhydrocodone / acetaminophenとIsoniazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isoniazidのその他の相互作用
よくある質問
Can I take Benzhydrocodone / acetaminophen with Isoniazid?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isoniazid inhibits CYP3A4, which clears hydrocodone, so opioid exposure can increase and risk respiratory depression and sedation. Isoniazid and acetaminophen both carry hepatotoxic potential, with isoniazid possibly increasing toxic acetaminophen metabolite formation.
How serious is the interaction between Benzhydrocodone / acetaminophen and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation and respiratory depression. Monitor liver function and limit acetaminophen total daily dose.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Carbamazepine, Didanosine. The full list is on the Isoniazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
