相互作用
Belladonna and opium + Chlorpheniramine
重症度: 重大
Belladonna and opium and Chlorpheniramine: major interaction.
最終更新日 出典: US FDA label
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概要
The opium component adds CNS and respiratory depression to the sedation of chlorpheniramine, and belladonna adds anticholinergic burden. The combination can cause marked drowsiness, constipation, urinary retention and confusion.
この相互作用をわかりやすく説明すると
Belladonna and opium and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive opioid CNS and respiratory depression plus additive anticholinergic effects.
対処法
Avoid if possible; otherwise use the lowest doses and monitor sedation, respiration and anticholinergic effects. Use a non-sedating antihistamine instead.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Belladonna and opiumとChlorpheniramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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参考文献
Chlorpheniramineのその他の相互作用
- Benzhydrocodone / acetaminophen + Chlorpheniramine 重大
- Brexanolone + Chlorpheniramine 重大
- Buprenorphine long-acting + Chlorpheniramine 重大
- Buprenorphine subdermal implant + Chlorpheniramine 重大
- Buprenorphine transdermal + Chlorpheniramine 重大
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine 重大
よくある質問
Can I take Belladonna and opium with Chlorpheniramine?
MediHelp rates the interaction as major. Belladonna and opium and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The opium component adds CNS and respiratory depression to the sedation of chlorpheniramine, and belladonna adds anticholinergic burden. The combination can cause marked drowsiness, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest doses and monitor sedation, respiration and anticholinergic effects. Use a non-sedating antihistamine instead.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine long-acting. The full list is on the Chlorpheniramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
