相互作用
Buprenorphine transdermal + Chlorpheniramine
重症度: 重大
Buprenorphine transdermal and Chlorpheniramine: major interaction.
最終更新日
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概要
Chlorpheniramine adds sedating effects to buprenorphine, increasing the risk of drowsiness and respiratory depression. Patch effects persist after removal.
この相互作用をわかりやすく説明すると
Buprenorphine transdermal and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression from an opioid and a sedating antihistamine.
対処法
Prefer a non-sedating antihistamine. If combined, use the lowest effective chlorpheniramine dose and monitor for sedation and respiratory depression.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine transdermalとChlorpheniramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Chlorpheniramineのその他の相互作用
よくある質問
Can I take Buprenorphine transdermal with Chlorpheniramine?
MediHelp rates the interaction as major. Buprenorphine transdermal and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpheniramine adds sedating effects to buprenorphine, increasing the risk of drowsiness and respiratory depression. Patch effects persist after removal.
How serious is the interaction between Buprenorphine transdermal and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine. If combined, use the lowest effective chlorpheniramine dose and monitor for sedation and respiratory depression.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
