相互作用
Brexanolone + Chlorpheniramine
重症度: 重大
Brexanolone and Chlorpheniramine: major interaction.
最終更新日
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概要
Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
この相互作用をわかりやすく説明すると
Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression via GABA-A modulation and H1 antagonism.
対処法
Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrexanoloneとChlorpheniramineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を7日間無料でお試し。カード登録不要。
Chlorpheniramineのその他の相互作用
- Belladonna and opium + Chlorpheniramine 重大
- Benzhydrocodone / acetaminophen + Chlorpheniramine 重大
- Buprenorphine long-acting + Chlorpheniramine 重大
- Buprenorphine subdermal implant + Chlorpheniramine 重大
- Buprenorphine transdermal + Chlorpheniramine 重大
- Calcium / magnesium / potassium / sodium oxybates + Chlorpheniramine 重大
よくある質問
Can I take Brexanolone with Chlorpheniramine?
MediHelp rates the interaction as major. Brexanolone and Chlorpheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness, and CNS depressants such as chlorpheniramine may add to this risk.
How serious is the interaction between Brexanolone and Chlorpheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and oxygen saturation continuously during the infusion. Hold the antihistamine or reduce the brexanolone dose if sedation occurs.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Buprenorphine long-acting. The full list is on the Chlorpheniramine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
