相互作用
Benazepril + Empagliflozin-linagliptin
重症度: 中等度
Benazepril and Empagliflozin-linagliptin: moderate interaction.
最終更新日
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概要
DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
この相互作用をわかりやすく説明すると
Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Empagliflozin-linagliptin belongs to Endocrine.
なぜ起こるのか
Additive reduction in bradykinin and substance P degradation through ACE and DPP-4 inhibition.
対処法
Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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アカウントを作成してPro+トライアルを始めると、BenazeprilとEmpagliflozin-linagliptinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Empagliflozin-linagliptinのその他の相互作用
Benazeprilのその他の相互作用
よくある質問
Can I take Benazepril with Empagliflozin-linagliptin?
MediHelp rates the interaction as moderate. Benazepril and Empagliflozin-linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. DPP-4 inhibitors such as linagliptin reduce breakdown of substance P and bradykinin, which are also affected by ACE inhibitors. Taking both may raise the risk of angioedema, though absolute risk remains small.
How serious is the interaction between Benazepril and Empagliflozin-linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report swelling of the lips, tongue or face immediately. Stop the ACE inhibitor and treat if angioedema occurs, and use an alternative antihypertensive class in patients with prior angioedema.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
