相互作用
Bendroflumethiazide + Hydrochlorothiazide-lisinopril
重症度: 重大
Bendroflumethiazide and Hydrochlorothiazide-lisinopril: major interaction.
最終更新日
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概要
Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without clear added benefit.
この相互作用をわかりやすく説明すると
Bendroflumethiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Duplicate inhibition of the distal tubule sodium-chloride cotransporter with additive electrolyte loss and volume depletion.
対処法
Avoid using two thiazides together and stop one of them. Monitor electrolytes and renal function if overlap occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BendroflumethiazideとHydrochlorothiazide-lisinoprilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydrochlorothiazide-lisinoprilのその他の相互作用
よくある質問
Can I take Bendroflumethiazide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Bendroflumethiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together and stop one of them. Monitor electrolytes and renal function if overlap occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
