相互作用
Candesartan + Hydrochlorothiazide-lisinopril
重症度: 重大
Candesartan and Hydrochlorothiazide-lisinopril: major interaction.
最終更新日
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概要
Combining an ARB with an ACE inhibitor gives dual renin-angiotensin blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit. Hydrochlorothiazide only partly offsets the potassium rise.
この相互作用をわかりやすく説明すると
Candesartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
なぜ起こるのか
Dual blockade of the renin-angiotensin-aldosterone system at two points.
対処法
Avoid combining an ARB with lisinopril except in specialist-supervised situations. If used, monitor potassium and creatinine closely.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CandesartanとHydrochlorothiazide-lisinoprilの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Hydrochlorothiazide-lisinoprilのその他の相互作用
- Dofetilide + Hydrochlorothiazide-lisinopril 併用禁忌
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan 併用禁忌
- Amifostine + Hydrochlorothiazide-lisinopril 重大
- Amiloride + Hydrochlorothiazide-lisinopril 重大
- Benazepril + Hydrochlorothiazide-lisinopril 重大
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril 重大
Candesartanのその他の相互作用
よくある質問
Can I take Candesartan with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Candesartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ARB with an ACE inhibitor gives dual renin-angiotensin blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit. Hydrochlorothiazide only partly offsets the potassium rise.
How serious is the interaction between Candesartan and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining an ARB with lisinopril except in specialist-supervised situations. If used, monitor potassium and creatinine closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
