相互作用
Berotralstat + Tacrolimus
重症度: 重大
Berotralstat and Tacrolimus: major interaction.
最終更新日
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概要
Berotralstat inhibits P-gp and CYP3A4 and may raise tacrolimus concentrations. Because tacrolimus has a narrow therapeutic index, toxicity such as nephrotoxicity may result.
この相互作用をわかりやすく説明すると
Berotralstat and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
なぜ起こるのか
Inhibition of P-glycoprotein and CYP3A4 reduces tacrolimus efflux and metabolism.
対処法
Monitor tacrolimus trough concentrations and renal function when starting or stopping berotralstat, and reduce the tacrolimus dose as needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BerotralstatとTacrolimusの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tacrolimusのその他の相互作用
Berotralstatのその他の相互作用
よくある質問
Can I take Berotralstat with Tacrolimus?
MediHelp rates the interaction as major. Berotralstat and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits P-gp and CYP3A4 and may raise tacrolimus concentrations. Because tacrolimus has a narrow therapeutic index, toxicity such as nephrotoxicity may result.
How serious is the interaction between Berotralstat and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough concentrations and renal function when starting or stopping berotralstat, and reduce the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
