相互作用
Berotralstat + Quinine
重症度: 重大
Berotralstat and Quinine: major interaction.
最終更新日
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概要
Berotralstat inhibits CYP3A4 and P-glycoprotein, both of which affect quinine clearance, so quinine levels may rise. Berotralstat itself also prolongs the QT interval at higher doses, and quinine is a P-gp inhibitor that may raise berotralstat levels.
この相互作用をわかりやすく説明すると
Berotralstat and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Quinine belongs to Anti Parasitic.
なぜ起こるのか
Inhibition of CYP3A4 and P-glycoprotein by berotralstat reduces quinine clearance, with additive QT effects.
対処法
Avoid if possible because of the QT risk. If required, obtain an ECG, monitor for quinine toxicity such as cinchonism, and correct electrolytes.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BerotralstatとQuinineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Quinineのその他の相互作用
Berotralstatのその他の相互作用
よくある質問
Can I take Berotralstat with Quinine?
MediHelp rates the interaction as major. Berotralstat and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits CYP3A4 and P-glycoprotein, both of which affect quinine clearance, so quinine levels may rise. Berotralstat itself also prolongs the QT interval at higher doses, and quinine is a P-gp inhibitor that may raise berotralstat levels.
How serious is the interaction between Berotralstat and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible because of the QT risk. If required, obtain an ECG, monitor for quinine toxicity such as cinchonism, and correct electrolytes.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
