相互作用
Bethanechol + Physostigmine
重症度: 重大
Bethanechol and Physostigmine: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Physostigmine inhibits cholinesterase and increases acetylcholine, adding to the direct muscarinic stimulation of bethanechol. This can cause marked cholinergic toxicity including bradycardia, bronchospasm, salivation, vomiting and cramping.
この相互作用をわかりやすく説明すると
Bethanechol and Physostigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive cholinergic effect from direct muscarinic agonism plus inhibition of acetylcholine breakdown.
対処法
Avoid the combination where possible. If used, monitor heart rate, respiratory status and gastrointestinal symptoms, and have atropine available.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BethanecholとPhysostigmineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Bethanecholのその他の相互作用
よくある質問
Can I take Bethanechol with Physostigmine?
MediHelp rates the interaction as major. Bethanechol and Physostigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Physostigmine inhibits cholinesterase and increases acetylcholine, adding to the direct muscarinic stimulation of bethanechol. This can cause marked cholinergic toxicity including bradycardia, bronchospasm, salivation, vomiting and cramping.
How serious is the interaction between Bethanechol and Physostigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor heart rate, respiratory status and gastrointestinal symptoms, and have atropine available.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
