相互作用
Bevacizumab + Efgartigimod / hyaluronidase sc
重症度: 中等度
Bevacizumab and Efgartigimod / hyaluronidase sc: moderate interaction.
最終更新日
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概要
Subcutaneous efgartigimod blocks the neonatal Fc receptor, which may speed clearance of IgG antibodies such as bevacizumab and lower their exposure.
この相互作用をわかりやすく説明すると
Bevacizumab and Efgartigimod / hyaluronidase sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
FcRn blockade reduces IgG recycling and shortens the half-life of IgG monoclonal antibodies.
対処法
Monitor for reduced bevacizumab response; consider alternatives to either drug if long-term combination is needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BevacizumabとEfgartigimod / hyaluronidase scの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bevacizumabのその他の相互作用
よくある質問
Can I take Bevacizumab with Efgartigimod / hyaluronidase sc?
MediHelp rates the interaction as moderate. Bevacizumab and Efgartigimod / hyaluronidase sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Subcutaneous efgartigimod blocks the neonatal Fc receptor, which may speed clearance of IgG antibodies such as bevacizumab and lower their exposure.
How serious is the interaction between Bevacizumab and Efgartigimod / hyaluronidase sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bevacizumab response; consider alternatives to either drug if long-term combination is needed.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
