相互作用
Bevacizumab + Sunitinib
重症度: 重大
Bevacizumab and Sunitinib: major interaction.
最終更新日
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概要
Combining these two anti-angiogenic agents has led to microangiopathic hemolytic anemia in patients with metastatic renal cell carcinoma. Hypertension and thrombocytopenia have also been seen, which makes the combination poorly tolerated.
この相互作用をわかりやすく説明すると
Bevacizumab and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bevacizumab belongs to Oncology; Sunitinib belongs to Oncology.
なぜ起こるのか
Combined inhibition of VEGF signalling at the ligand and receptor tyrosine kinase level causing endothelial injury and microangiopathy; exact mechanism is not fully defined.
対処法
Avoid concurrent use. If microangiopathic hemolytic anemia is suspected, check hemoglobin, platelets, LDH, haptoglobin and a blood smear, and stop the drugs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BevacizumabとSunitinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Bevacizumabのその他の相互作用
Sunitinibのその他の相互作用
よくある質問
Can I take Bevacizumab with Sunitinib?
MediHelp rates the interaction as major. Bevacizumab and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining these two anti-angiogenic agents has led to microangiopathic hemolytic anemia in patients with metastatic renal cell carcinoma. Hypertension and thrombocytopenia have also been seen, which makes the combination poorly tolerated.
How serious is the interaction between Bevacizumab and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If microangiopathic hemolytic anemia is suspected, check hemoglobin, platelets, LDH, haptoglobin and a blood smear, and stop the drugs.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Daunorubicin, Dengue vaccine, Doxorubicin. The full list is on the Bevacizumab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
