相互作用
Blinatumomab + Cyclosporin
重症度: 中等度
Blinatumomab and Cyclosporin: moderate interaction.
最終更新日
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概要
Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
この相互作用をわかりやすく説明すると
Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Cyclosporin belongs to Miscellaneous.
なぜ起こるのか
Cytokine release (e.g., IL-6) transiently downregulates CYP450 enzymes, reducing cyclosporine metabolism.
対処法
Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BlinatumomabとCyclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Blinatumomabのその他の相互作用
よくある質問
Can I take Blinatumomab with Cyclosporin?
MediHelp rates the interaction as moderate. Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
