相互作用
Blinatumomab + Tacrolimus
重症度: 中等度
Blinatumomab and Tacrolimus: moderate interaction.
最終更新日
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概要
Cytokine release at the start of blinatumomab treatment can temporarily suppress CYP450 enzymes, which may raise tacrolimus concentrations. Elevated tacrolimus levels increase the risk of nephrotoxicity and neurotoxicity.
この相互作用をわかりやすく説明すると
Blinatumomab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Tacrolimus belongs to Miscellaneous.
なぜ起こるのか
Transient cytokine-mediated suppression of CYP3A4 reduces tacrolimus metabolism.
対処法
Monitor tacrolimus trough levels and renal function closely during the first days of each blinatumomab cycle. Reduce the tacrolimus dose as needed.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BlinatumomabとTacrolimusの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Tacrolimusのその他の相互作用
Blinatumomabのその他の相互作用
よくある質問
Can I take Blinatumomab with Tacrolimus?
MediHelp rates the interaction as moderate. Blinatumomab and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release at the start of blinatumomab treatment can temporarily suppress CYP450 enzymes, which may raise tacrolimus concentrations. Elevated tacrolimus levels increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function closely during the first days of each blinatumomab cycle. Reduce the tacrolimus dose as needed.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
