相互作用
Bosentan + Glyburide-metformin
重症度: 併用禁忌
Bosentan and Glyburide-metformin: contraindicated interaction.
最終更新日
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概要
Bosentan lowers glyburide exposure through CYP induction, weakening glycaemic control, and the pairing is associated with a higher rate of liver aminotransferase elevations. Bosentan labelling lists glyburide as contraindicated.
この相互作用をわかりやすく説明すると
Bosentan and Glyburide-metformin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bosentan belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
なぜ起こるのか
Bosentan CYP2C9/3A4 induction reduces glibenclamide levels; additive hepatocellular toxicity
対処法
Do not combine; use a different hypoglycaemic agent (for example insulin or a non-sulfonylurea) and monitor liver tests per bosentan labelling.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosentanとGlyburide-metforminの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glyburide-metforminのその他の相互作用
Bosentanのその他の相互作用
よくある質問
Can I take Bosentan with Glyburide-metformin?
MediHelp rates the interaction as contraindicated. Bosentan and Glyburide-metformin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bosentan lowers glyburide exposure through CYP induction, weakening glycaemic control, and the pairing is associated with a higher rate of liver aminotransferase elevations. Bosentan labelling lists glyburide as contraindicated.
How serious is the interaction between Bosentan and Glyburide-metformin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a different hypoglycaemic agent (for example insulin or a non-sulfonylurea) and monitor liver tests per bosentan labelling.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Cholic acid, Clarithromycin, Contrast media. The full list is on the Glyburide-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
