相互作用
Cholic acid + Glyburide-metformin
重症度: 重大
Cholic acid and Glyburide-metformin: major interaction.
最終更新日
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概要
Glyburide inhibits the bile salt export pump and may cause accumulation of bile salts in hepatocytes. With cholic acid this raises the risk of liver injury.
この相互作用をわかりやすく説明すると
Cholic acid and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholic acid belongs to Gastrointestinal Tract; Glyburide-metformin belongs to Endocrine.
なぜ起こるのか
Glyburide inhibits BSEP, reducing hepatic bile salt efflux.
対処法
Avoid the combination where possible and choose an alternative antidiabetic agent. If it is unavoidable, monitor serum transaminases and bilirubin regularly.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Cholic acidとGlyburide-metforminの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glyburide-metforminのその他の相互作用
Cholic acidのその他の相互作用
よくある質問
Can I take Cholic acid with Glyburide-metformin?
MediHelp rates the interaction as major. Cholic acid and Glyburide-metformin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide inhibits the bile salt export pump and may cause accumulation of bile salts in hepatocytes. With cholic acid this raises the risk of liver injury.
How serious is the interaction between Cholic acid and Glyburide-metformin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative antidiabetic agent. If it is unavoidable, monitor serum transaminases and bilirubin regularly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Clarithromycin, Contrast media. The full list is on the Glyburide-metformin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
