相互作用
Bosentan + Glyburide
重症度: 併用禁忌
Bosentan and Glyburide: contraindicated interaction.
最終更新日
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概要
Bosentan lowers glyburide exposure through CYP induction, weakening glycaemic control, and the pairing is associated with a higher rate of liver aminotransferase elevations. Bosentan labelling lists glyburide as contraindicated.
この相互作用をわかりやすく説明すると
Bosentan and Glyburide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bosentan belongs to Miscellaneous; Glyburide belongs to Endocrine.
なぜ起こるのか
Bosentan CYP2C9/3A4 induction reduces glibenclamide levels; additive hepatocellular toxicity
対処法
Do not combine; use a different hypoglycaemic agent (for example insulin or a non-sulfonylurea) and monitor liver tests per bosentan labelling.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosentanとGlyburideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Glyburideのその他の相互作用
Bosentanのその他の相互作用
よくある質問
Can I take Bosentan with Glyburide?
MediHelp rates the interaction as contraindicated. Bosentan and Glyburide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Bosentan lowers glyburide exposure through CYP induction, weakening glycaemic control, and the pairing is associated with a higher rate of liver aminotransferase elevations. Bosentan labelling lists glyburide as contraindicated.
How serious is the interaction between Bosentan and Glyburide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a different hypoglycaemic agent (for example insulin or a non-sulfonylurea) and monitor liver tests per bosentan labelling.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Cholic acid, Ciprofloxacin, Clarithromycin. The full list is on the Glyburide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
