相互作用
Ciprofloxacin + Glyburide
重症度: 重大
Ciprofloxacin and Glyburide: major interaction.
最終更新日
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概要
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, including cases needing hospitalization, has been reported with ciprofloxacin and glyburide, and the risk is higher in older or renally impaired patients. Ciprofloxacin may also modestly raise glyburide exposure.
この相互作用をわかりやすく説明すると
Ciprofloxacin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Glyburide belongs to Endocrine.
なぜ起こるのか
Fluoroquinolone effects on beta-cell insulin release add to sulfonylurea stimulation of insulin secretion, and ciprofloxacin may also reduce glyburide clearance.
対処法
Monitor blood glucose frequently during and after the antibiotic course and teach the patient to recognize hypoglycemia. Reduce the glyburide dose if glucose falls, or choose a non-fluoroquinolone antibiotic.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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アカウントを作成してPro+トライアルを始めると、CiprofloxacinとGlyburideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ciprofloxacinのその他の相互作用
Glyburideのその他の相互作用
よくある質問
Can I take Ciprofloxacin with Glyburide?
MediHelp rates the interaction as major. Ciprofloxacin and Glyburide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking sulfonylureas. Severe hypoglycemia, including cases needing hospitalization, has been reported with ciprofloxacin and glyburide, and the risk is higher in older or renally impaired patients. Ciprofloxacin may also modestly raise glyburide exposure.
How serious is the interaction between Ciprofloxacin and Glyburide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during and after the antibiotic course and teach the patient to recognize hypoglycemia. Reduce the glyburide dose if glucose falls, or choose a non-fluoroquinolone antibiotic.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
