相互作用
Bosutinib + Imatinib
重症度: 重大
Bosutinib and Imatinib: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Imatinib inhibits CYP3A4, the main enzyme clearing bosutinib, and can raise bosutinib exposure substantially. This increases the risk of bosutinib toxicity such as diarrhea, hepatotoxicity and myelosuppression. Both drugs are also BCR-ABL kinase inhibitors, so combining them offers little therapeutic rationale.
この相互作用をわかりやすく説明すると
Bosutinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Imatinib belongs to Oncology.
なぜ起こるのか
Imatinib inhibits CYP3A4-mediated metabolism of bosutinib, reducing its clearance.
対処法
Avoid the combination and choose a single BCR-ABL inhibitor appropriate to the disease. If unavoidable, monitor liver enzymes and gastrointestinal and hematologic toxicity closely and reduce the bosutinib dose.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosutinibとImatinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Imatinibのその他の相互作用
Bosutinibのその他の相互作用
よくある質問
Can I take Bosutinib with Imatinib?
MediHelp rates the interaction as major. Bosutinib and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imatinib inhibits CYP3A4, the main enzyme clearing bosutinib, and can raise bosutinib exposure substantially. This increases the risk of bosutinib toxicity such as diarrhea, hepatotoxicity and myelosuppression. Both drugs are also BCR-ABL kinase inhibitors, so combining them offers little therapeutic rationale.
How serious is the interaction between Bosutinib and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a single BCR-ABL inhibitor appropriate to the disease. If unavoidable, monitor liver enzymes and gastrointestinal and hematologic toxicity closely and reduce the bosutinib dose.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
