相互作用
Bosutinib + Oxcarbazepine
重症度: 重大
Bosutinib and Oxcarbazepine: major interaction.
最終更新日
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概要
Oxcarbazepine may lower bosutinib exposure and reduce antileukemic efficacy. Strong inducers lower exposure dramatically; oxcarbazepine's effect is likely smaller but still relevant.
この相互作用をわかりやすく説明すると
Bosutinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
なぜ起こるのか
CYP3A4 induction by oxcarbazepine increases bosutinib metabolism.
対処法
Use a non-inducing anticonvulsant where possible. If coadministered, monitor hematologic and molecular response.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BosutinibとOxcarbazepineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Oxcarbazepineのその他の相互作用
Bosutinibのその他の相互作用
よくある質問
Can I take Bosutinib with Oxcarbazepine?
MediHelp rates the interaction as major. Bosutinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may lower bosutinib exposure and reduce antileukemic efficacy. Strong inducers lower exposure dramatically; oxcarbazepine's effect is likely smaller but still relevant.
How serious is the interaction between Bosutinib and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant where possible. If coadministered, monitor hematologic and molecular response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
