相互作用
Brexanolone + Eszopiclone
重症度: 重大
Brexanolone and Eszopiclone: major interaction.
最終更新日
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概要
Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and eszopiclone adds further CNS depression. The risk of oversedation is increased when they are used together.
この相互作用をわかりやすく説明すると
Brexanolone and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS depression via positive allosteric modulation of GABA-A receptors by both drugs.
対処法
Monitor continuously for sedation and hypoxia during the infusion, as required for brexanolone. Hold or reduce eszopiclone and the brexanolone infusion if excessive sedation occurs.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrexanoloneとEszopicloneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Eszopicloneのその他の相互作用
よくある質問
Can I take Brexanolone with Eszopiclone?
MediHelp rates the interaction as major. Brexanolone and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes excessive sedation and sudden loss of consciousness in some patients, and eszopiclone adds further CNS depression. The risk of oversedation is increased when they are used together.
How serious is the interaction between Brexanolone and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion, as required for brexanolone. Hold or reduce eszopiclone and the brexanolone infusion if excessive sedation occurs.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
