相互作用
Buprenorphine long-acting + Eszopiclone
重症度: 重大
Buprenorphine long-acting and Eszopiclone: major interaction.
最終更新日
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概要
Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Long-acting injection formulations cannot be quickly withdrawn if problems arise.
この相互作用をわかりやすく説明すると
Buprenorphine long-acting and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive CNS and respiratory depression from opioid receptor agonism plus GABA-A potentiation.
対処法
Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression, and counsel the patient and caregivers.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Buprenorphine long-actingとEszopicloneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Eszopicloneのその他の相互作用
よくある質問
Can I take Buprenorphine long-acting with Eszopiclone?
MediHelp rates the interaction as major. Buprenorphine long-acting and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Long-acting injection formulations cannot be quickly withdrawn if problems arise.
How serious is the interaction between Buprenorphine long-acting and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression, and counsel the patient and caregivers.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
