相互作用
Brimonidine + Rasagiline
重症度: 併用禁忌
Brimonidine and Rasagiline: contraindicated interaction.
最終更新日
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概要
Brimonidine labelling forbids use with MAO inhibitors, and rasagiline is an irreversible MAO-B inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
この相互作用をわかりやすく説明すると
Brimonidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Rasagiline belongs to Central Nervous System.
なぜ起こるのか
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
対処法
Avoid brimonidine in patients taking rasagiline; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrimonidineとRasagilineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Rasagilineのその他の相互作用
Brimonidineのその他の相互作用
よくある質問
Can I take Brimonidine with Rasagiline?
MediHelp rates the interaction as contraindicated. Brimonidine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and rasagiline is an irreversible MAO-B inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking rasagiline; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Bupropion-naltrexone, Bupropion. The full list is on the Rasagiline page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
