相互作用
Brimonidine + Isocarboxazid
重症度: 併用禁忌
Brimonidine and Isocarboxazid: contraindicated interaction.
最終更新日
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概要
Brimonidine labelling forbids use with MAO inhibitors, and isocarboxazid is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
この相互作用をわかりやすく説明すると
Brimonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Isocarboxazid belongs to Central Nervous System.
なぜ起こるのか
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
対処法
Avoid brimonidine in patients taking isocarboxazid; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BrimonidineとIsocarboxazidの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Isocarboxazidのその他の相互作用
Brimonidineのその他の相互作用
よくある質問
Can I take Brimonidine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Brimonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and isocarboxazid is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking isocarboxazid; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
