相互作用
Budesonide + Darunavir
重症度: 重大
Budesonide and Darunavir: major interaction.
最終更新日
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概要
Darunavir, especially when boosted with ritonavir or cobicistat, increases systemic budesonide exposure and can lead to Cushing's syndrome and adrenal suppression. Budesonide does not meaningfully alter darunavir levels.
この相互作用をわかりやすく説明すると
Budesonide and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide belongs to Respiratory; Darunavir belongs to Anti Virals.
なぜ起こるのか
Inhibition of CYP3A4 metabolism of budesonide by darunavir and its pharmacokinetic booster.
対処法
Avoid long-term coadministration and consider beclomethasone as an alternative. If used, monitor for Cushingoid features and adrenal suppression.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BudesonideとDarunavirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Budesonideのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Budesonide with Darunavir?
MediHelp rates the interaction as major. Budesonide and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, especially when boosted with ritonavir or cobicistat, increases systemic budesonide exposure and can lead to Cushing's syndrome and adrenal suppression. Budesonide does not meaningfully alter darunavir levels.
How serious is the interaction between Budesonide and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term coadministration and consider beclomethasone as an alternative. If used, monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Aldesleukin, Atazanavir, Bcg vaccine live. The full list is on the Budesonide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
