相互作用
Darunavir + Eletriptan
重症度: 併用禁忌
Darunavir and Eletriptan: contraindicated interaction.
最終更新日
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概要
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can greatly raise eletriptan exposure. This increases the risk of serious vasoconstrictive effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors.
この相互作用をわかりやすく説明すると
Darunavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Eletriptan belongs to Central Nervous System.
なぜ起こるのか
Potent inhibition of CYP3A4-mediated eletriptan metabolism, mainly via the ritonavir or cobicistat booster.
対処法
Do not give eletriptan within 72 hours of boosted darunavir. Use a triptan that is not metabolized by CYP3A4, such as sumatriptan or rizatriptan.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとEletriptanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Eletriptanのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Eletriptan?
MediHelp rates the interaction as contraindicated. Darunavir and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and can greatly raise eletriptan exposure. This increases the risk of serious vasoconstrictive effects. Eletriptan labeling contraindicates use within 72 hours of potent CYP3A4 inhibitors.
How serious is the interaction between Darunavir and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give eletriptan within 72 hours of boosted darunavir. Use a triptan that is not metabolized by CYP3A4, such as sumatriptan or rizatriptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
