相互作用
Darunavir + Flibanserin
重症度: 併用禁忌
Darunavir and Flibanserin: contraindicated interaction.
最終更新日
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概要
Darunavir, usually given with a booster, inhibits CYP3A4 and can markedly increase flibanserin concentrations. This raises the risk of severe hypotension, syncope and CNS depression.
この相互作用をわかりやすく説明すると
Darunavir and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Flibanserin belongs to Genitourinary.
なぜ起こるのか
Inhibition of CYP3A4 reduces first-pass and systemic metabolism of flibanserin.
対処法
Avoid the combination; do not start flibanserin in patients taking darunavir regimens. Choose a non-interacting approach for the sexual dysfunction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DarunavirとFlibanserinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Flibanserinのその他の相互作用
Darunavirのその他の相互作用
よくある質問
Can I take Darunavir with Flibanserin?
MediHelp rates the interaction as contraindicated. Darunavir and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with a booster, inhibits CYP3A4 and can markedly increase flibanserin concentrations. This raises the risk of severe hypotension, syncope and CNS depression.
How serious is the interaction between Darunavir and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; do not start flibanserin in patients taking darunavir regimens. Choose a non-interacting approach for the sexual dysfunction.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
